Flecainide: MedlinePlus Drug Information (2023)

pronounced like (flek' one side)

  • Why is this drug prescribed?
  • How should this remedy be used?
  • Other uses of this medicine
  • What special precautions should I follow?
  • What special dietary instructions should I follow?
  • What should I do if I miss a dose?
  • What side effects can this medicine cause?
  • What should I know about storing and disposing of this medicine?
  • In case of emergency/overdose
  • What other information do I need to know?
  • brand names


In a study of people who had a heart attack within the past 2 years, people who took flecainide were more likely to have another heart attack or die than people who didn't take flecainide. There is not enough information to say whether flecainide also increases the risk of heart attack or death in people who have not had a heart attack in the past 2 years. Because of this serious risk and because flecainide has not been shown to help people with irregular heartbeats live longer, flecainide should only be used to treat people with life-threatening irregular heartbeats.

Tell your doctor if you have atrial fibrillation or atrial fibrillation (conditions in which the upper chambers of the heart do not beat effectively). People with atrial fibrillation or atrial fibrillation who take flecainide may have a higher risk of developing certain types of irregular heartbeats.

Talk to your doctor about the risks of taking flecainide.

(Video) Flecainide (Tambocor) - Uses, Dosing, Side Effects | Medication Review

Why is this drug prescribed?

Flecainide is used to prevent certain types of life-threatening irregular heartbeats. Flecainide is in a class of drugs called antiarrhythmics. It works by decreasing the electrical signals in the heart to stabilize the heart rhythm.

Flecainide comes as a tablet to be taken by mouth. It is usually taken once every 12 hours. Some people may take flecainide once every 8 hours if they experience side effects or if their condition cannot be controlled by taking flecainide every 12 hours. Take flecainide at approximately the same times each day. Carefully follow the directions on the prescription label and ask your doctor or pharmacist to explain any parts you don't understand. Take flecainide exactly as directed. Do not take more or less or more often than prescribed by your doctor.

You may be hospitalized when starting treatment with flecainide. Your doctor will monitor you carefully during this time and as long as you continue to take flecainide. Your doctor will likely start you on a low dose of flecainide and gradually increase your dose, no more than once every 4 days. Your doctor may also lower your dose once your condition is under control.

Flecainide can control your condition but not cure it. Continue taking flecainide even if you feel well. Do not stop taking flecainide without talking to your doctor. If you suddenly stop taking flecainide, your condition may get worse.

Other uses of this medicine

This medication may be prescribed for other purposes; Ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking flecainide,

  • Tell your doctor and pharmacist if you are allergic to flecainide or any other medicine.
  • Tell your doctor and pharmacist what other prescription and over-the-counter drugs, vitamins, supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acetazolamide (Diamox); amiodarone (Cordarone, Pacerone); ammonium chloride; antacids; beta-blockers, such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); carbamazepine (Carbatrol, Tegretol); cimetidine (Tagamet); clozapine (Clozaril); dichlorphenamide; digoxin (Lanoxin); diltiazem (Cardizem, Tiazac); disopyramide (Norpace); methazolamide; nifedipine (Adalat, Procardia); phenytoin (Dilantin); phenobarbital; quinidine; baking soda (sodium bicarbonate, citric carbonate, mint); and verapamil (Calan, Verelan). Your doctor may need to change the dose of your medication or monitor you carefully for side effects.
  • Tell your doctor if you have heart block (a condition in which electrical signals are not sent normally from the upper chambers of the heart to the lower chambers). Your doctor may tell you not to take flecainide.
  • Tell your doctor if you have a pacemaker (a device surgically placed under the skin to control an irregular heartbeat) and if you have or have had a heart attack, heart failure, or any type of heart disease; low or high levels of potassium in the blood; or liver or kidney disease. Also inform your doctor if you follow a strictly vegetarian diet.
  • Tell your doctor if you are pregnant, planning to become pregnant or breast-feeding. Contact your doctor if you become pregnant while taking flecainide.
  • If you are going to have surgery, including dental surgery, tell your doctor or dentist that you are taking flecainide.
  • If you give this medicine to a child, be sure to talk to the doctor if there are any major changes in the amount of milk the baby drinks. Milk can affect how the medicine is absorbed by the body.
(Video) Flecainide and Propafenone - Class IC Antiarrhythmics Mechanism of Action, Side Effects & Indication

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue with your normal diet.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten dose.

What side effects can this medicine cause?

(Video) 💊 What is Flecainide?. Side effects, doses, warnings, uses and benefits of Flecainide (Tambocor).

Flecainide can cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dizziness
  • vision changes
  • headache
  • weakness
  • uncontrollable shaking of a part of your body
  • cold
  • abdominal pain

Some side effects can be serious. If you experience any of these symptoms, contact your doctor immediately:

  • fast, pounding, or irregular heartbeat
  • chest pain
  • shortness of breathe
  • extreme fatigue
  • nausea
  • loss of appetite
  • persistent cough with blood-tinged phlegm
  • swelling of the hands, feet, ankles, or legs
  • confusion
  • unusual bleeding or bruising
  • pain in the upper right part of the abdomen
  • yellowing of the skin or eyes
  • flu-like symptoms

Flecainide can cause other side effects. Contact your doctor if you experience any unusual problems while taking this medicine.

If you have a serious side effect, you or your doctor can submit a report to the Food and Drug Administration (FDA) MedWatch Adverse Event Reporting Program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storing and disposing of this medicine?

Keep this medicine in the container it came in, tightly closed and out of the reach of children. Store at room temperature and away from excess heat and moisture (not in the bathroom).

Unnecessary medicines must be disposed of in a special way to ensure that pets, children and other people cannot ingest them. However, you should not flush this medicine down the toilet. Instead, the best way to dispose of your medication is through a medication take-back program. Talk to your pharmacist or contact your local waste/recycling department to learn more about take-back programs in your community. Consult the FDA website for safe disposal of medications (http://goo.gl/c4Rm4p) for more information if you don't have access to a return program.

It is important to keep all medications out of the sight and reach of children, as many containers (such as containers for weekly pills and eye drops, creams, patches, and inhalers) are not child-resistant and small children can easily open them. To protect children from poisoning, always lock the safety caps and immediately place the medicine in a safe place - one that is out of sight and reach.http://www.upandaway.org

In case of emergency/overdose

(Video) Anti-arrhythmic drugs - Class 1C agents

In case of overdose, call the Poison Control Hotline at 1-800-222-1222. Information is also available online athttps://www.poisonhelp.org/help. If the victim has passed out, has had a seizure, is having trouble breathing, or cannot be woken up, call 911 immediately.

Overdose symptoms can include:

  • nausea
  • vomit
  • attack
  • slow, fast, or irregular heartbeat
  • loss of consciousness
  • sudden death

What other information do I need to know?

Keep all appointments with your doctor and laboratory. Your doctor will order some laboratory tests to check your body's response to flecainide.

Do not let other people take your medicine. Ask questions at the pharmacy about how to refill your prescription.

It is important that you keep a written list of all prescription and nonprescription (over-the-counter) medications you take, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you whenever you visit a doctor or if you are admitted to a hospital. It's also important information to have with you in case of an emergency.

(Video) Propafenone (Rythmol) - Uses, Dosing, Side Effects | Medication Review

brand names

  • Tambocor®
Last revision -15/09/2016

Research drugs and medications


What is the warning for flecainide? ›

Flecainide may cause some people to become dizzy, lightheaded, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

What to avoid when taking flecainide? ›

Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Flecainide may cause a condition that affects the heart rhythm (QT prolongation).

Is flecainide a high risk drug? ›

Flecainide is associated with some health risks, including possible: Allergic reaction. Heart attack in people who have already had a heart attack. New or worse arrhythmia.

When should you not use flecainide? ›

Flecainide has an FDA Black Box Warning recommending restricting its use to life-threatening ventricular arrhythmias, as data show no surn=vival benefits without such arrhythmias. Proarrythmic effects may occur in atrial flutter or atrial fibrillation; the drug is not recommended for chronic atrial fibrillation.

Who should not take flecainide? ›

Flecainide is not recommended if you have chronic atrial fibrillation. For people with abnormal heart rhythm: Flecainide may cause new or worsened abnormal heart rhythms. Depending on your condition, your doctor may first give you this medication in the hospital so that your heart rhythms can be closely monitored.

Does flecainide raise blood pressure? ›

In comparison with propranolol, flecainide increased heart rate and QRS duration (p less than 0.01, p less than 0.001 respectively). It increased diastolic BP, PR interval, QS2-Index, PEP, and PEP/LVET ratio, and decreased LVET-Index (p less than 0.05).

Can you drink coffee when taking flecainide? ›

The metabolism of Flecainide can be decreased when combined with Caffeine.

Does flecainide affect sleep? ›

Similarly, the labeling for flecainide describes a high level of CNS adverse effects including dizziness (19-30%), visual disturbances (16%), fatigue (8%) and somnolence and insomnia at a frequency between 1% and 3%.

Is 200 mg of flecainide a lot? ›

Adults—At first, 100 milligrams (mg) every 12 hours. Your doctor may increase your dose as needed. However, the dose is usually not more than 400 mg per day.

Is flecainide safe for elderly? ›

No information is available on the relationship of age to the effects of flecainide in elderly patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving flecainide.

What is the safest drug for AFIB? ›

Of all antiarrhythmic agents, dofetilide and amiodarone have been proven safe in patients with heart failure.

Which is better flecainide or metoprolol? ›

Flecainide has an average rating of 7.3 out of 10 from a total of 168 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 20% reported a negative effect. Metoprolol has an average rating of 5.7 out of 10 from a total of 620 ratings on Drugs.com.

What is the success rate of flecainide? ›

Flecainide was the most effective drug, with a primary response rate of 95% (see Figure 5).

What is the first drug of choice for atrial fibrillation? ›

A beta blocker, such as bisoprolol or atenolol, or a calcium channel blocker, such as verapamil or diltiazem, will be prescribed. The medicine you'll be offered will depend on what symptoms you're having and your general health. A medicine called digoxin may be offered if other drugs are not suitable.

Is flecainide good for your heart? ›

Flecainide is also used to prevent life-threatening sustained ventricular tachycardia (sustained VT). Flecainide belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep the heart rhythm normal.

Does flecainide stop palpitations? ›

Flecainide is used to treat arrhythmias. An arrhythmia is an irregularity in your heartbeat, which causes your heart to skip a beat, beat unevenly or beat very fast or very slowly. Flecainide works by correcting irregular heartbeats to a normal rhythm and by slowing an overactive heart.

Can flecainide put your heart back in rhythm? ›

Flecainide is in a class of medications called antiarrhythmics. It works by slowing electrical signals in the heart to stabilize the heart rhythm.

Can flecainide cause a fib? ›

Flecainide-induced arrhythmias include sinus bradycardia or arrest in 2%, bundle branch blocks in 1%, increased premature ventricular depolarizations in 1%, ventricular tachycardia or fibrillation in 0.5%, and sudden death in 0.2% of patients.

Does flecainide make you tired? ›

Abstract. Introduction: Flecainide is an anti-arrhythmic used in patients with symptomatic arrhythmias without structural heart anomalies. It is known to cause several non-cardiac adverse reactions, most commonly headaches, dizziness, fatigue and nausea.

Does flecainide make you urinate? ›

Call your doctor at once if you have a serious side effect such as weak pulse, slow breathing, fast or uneven heartbeat, feeling like you might pass out, feeling short of breath, swelling, rapid weight gain, confusion, extreme thirst, increased urination, muscle weakness, or jaundice (yellowing of the skin or eyes).

Can flecainide damage kidneys? ›

Despite its growing use, the presenting signs and symptoms of flecainide toxicity are not familiar to most clinicians. In particular, our patient's particular presentation of acute kidney injury (AKI) resulting in flecainide accumulation is high risk for missed diagnosis in the emergency department.

Can you take vitamin D with flecainide? ›

No interactions were found between flecainide and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Why take metoprolol with flecainide? ›

Conclusion: Flecainide-metoprolol combination therapy improves effectiveness of rhythm control in persistent symptomatic AF and increases tolerability, with a concomitant reduction of side effects and a better compliance.

Can I take Tylenol with flecainide? ›

Interactions between your drugs

No interactions were found between flecainide and Tylenol. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

What is the peak time for flecainide? ›

The peak flecainide plasma concentration is generally reached within 2-3 hours. Flecainide does not undergo any significant first-pass metabolism. In vitro, flecainide is approximately 40%-50% bound to plasma proteins.

Can flecainide cause eye problems? ›

Results: 10.5% of the patients had blurred vision on lateral gaze lasting for a couple of seconds.

How long does it take for flecainide to act? ›

The single dose oral loading regimen of flecainide appears to be effective for cardioversion of recent-onset atrial fibrillation with a relatively rapid effect within 2-4 h, and is free of serious complications in patients without structural heart disease.

Can you drink milk with flecainide? ›

Milk (including breastmilk and infant formula) may reduce the amount of flecainide absorbed from the stomach. Flecainide doses should be given at least 30 minutes either side of milk or milk feeds.

Can you take metoprolol and flecainide together? ›

metoprolol flecainide

Using metoprolol together with flecainide may have additive effects. Contact your doctor if you experience dizziness, slow or irregular heartbeats, fainting, or palpitations. You may need a dose adjustment or special tests to safely use both medications.

How do you stop an AFIB episode? ›

Ways a person can try to stop an A-fib episode on their own include taking slow, deep breaths, or coughing. The ideal way for a person to stop an A-fib episode is to see a doctor for evaluation and treatment of their symptoms, including treatment of any underlying disorders.

How long can an 80 year old live with AFib? ›

What's the Outlook for Older Adults With AFib? Men between the ages 55-74 with AFib have a 61.5% death rate within 10 years of diagnosis. This is compared to a 30% rate in men who don't have the condition. Women of the same age with AFib had a 10-year death rate of 57.6% versus 20.9% in women without AFib.

Can you live with AFib without treatment? ›

With the right treatment and regular management, most people with persistent atrial fibrillation can live active, healthy lives. The longer persistent Afib goes without treatment, however, the harder it is to manage. It may become permanent or lead to severe complications such as blood clots or stroke.

What percentage of people over 80 have AFib? ›

Its prevalence in the general population increases steadily with advancing age, from 0.12–0.16% in people younger than 49 years to 3.7–4.2% in those aged 60–70 years. Beyond the age of 80 years, prevalence can be as high as 10–17% (6).

What is the newest treatment for atrial fibrillation? ›

WEDNESDAY, March 8, 2023 (HealthDay News) -- A quicker, safer option for treating an irregular heartbeat called atrial fibrillation might be just months away. Atrial fibrillation is currently treated with drugs or a procedure known as thermal ablation.

What can worsen atrial fibrillation? ›

drinking excessive amounts of alcohol, particularly binge drinking. being overweight (read about how to lose weight) drinking lots of caffeine, such as tea, coffee or energy drinks. taking illegal drugs, particularly amphetamines or cocaine.

What is the safest blood thinner to take for AFib? ›

The most recent guidelines from the American College of Cardiology (ACC) and the American Heart Association (AHA) recommend DOACs as the best blood thinners for AFib in most people.

Do I need a beta blocker with flecainide? ›

If you are prescribed flecainide, you may also have to take a beta block or calcium channel blocker. This is to protect the lower chambers of the heart (ventricles) from contracting too quickly.

What is the pill in the pocket for flecainide? ›

What is the “pill-in-the-pocket” approach? The “pill-in-the-pocket” approach is the administration of a prescribed class IC antiarrhythmic, either flecainide or propafenone, following recent onset of episodes of palpitations in patients with paroxysmal AF.

Can metoprolol stop AFIB? ›

It has been shown recently that the beta-blocker metoprolol controlled release/extended release (CR/XL) is also effective in maintaining sinus rhythm after conversion of atrial fibrillation.

Does flecainide stop working after a while? ›

Background: Flecainide loses its efficacy to cardiovert when AF has been present for more than 24 hours. Most probably, the loss is caused by atrial electrical remodeling. Studies suggest electrical remodeling is completely reversible within 4 days after restoration of sinus rhythm (SR).

Why does flecainide cause atrial flutter? ›

Atrial proarrhythmia has been described as the development of a persistent atrial arrhythmia that is either new or was previously paroxysmal. Flecainide slows conduction through the atrial tissue more than it prolongs refractoriness, which enables organized AF activity and promotes atrial flutter.

Can you live with AFib without blood thinners? ›

While patients who have elevated stroke risks may be able to manage symptoms of AFib — such as a racing heartbeat — with other medications or medical procedures, they will still need to take blood thinners to protect against stroke.

How do I get my heart back in rhythm naturally? ›

Exercise regularly

Exercise can improve overall cardiovascular health and help restore the heart's natural rhythm. It can also help reduce stress and anxiety. Cardiovascular exercise helps strengthen the heart, which can prevent or reduce palpitations.

What are 4 common drugs tied to AFib? ›

Cocaine, methamphetamine, opioids, and cannabis may independently increase risk of atrial fibrillation (AFib), based on data from almost 24 million people.

What can I take instead of flecainide? ›

Is there an alternative to flecainide? There are many other antiarrhythmic medications that treat the same conditions as flecainide, such as propafenone, sotalol, or amiodarone.

What is the mortality rate of flecainide? ›

Eight deaths were reported during a mean follow-up of 3.4 ± 2.4 years. Compared to the general population, the standardized mortality ratios were 1.57 (95% confidence interval (CI) 0.68–3.09) for all-cause mortality and 4.16 (95% CI 1.53–9.06) for death from cardiovascular disease.

What is the risk of flecainide challenge? ›

The Adrenaline Challenge Test is safe, however as with any procedure, there is potential risk that may occur during or after procedure. It is common to experience a sensation of an increased heart rate, that your heart feels like it is beating harder and to feel sweaty during this procedure.

What level of flecainide is toxic? ›

Flecainide has a narrow therapeutic index (0.2-1.0 mcg/mL), which increases the potential for toxicity. Some patients may even experience symptoms of toxicity at lower serum levels (as low as 0.7 mcg/mL or higher) [4].

Is 50 mg of flecainide a lot? ›

The typical adult starting dose is 50 mg to 100 mg by mouth twice a day, and the maximum recommended daily dose is 300 mg to 400 mg per day depending on the reason for use.

What is the safest AFib medication? ›

Of all antiarrhythmic agents, dofetilide and amiodarone have been proven safe in patients with heart failure.

What is the best drug to stop atrial fibrillation episodes? ›

Beta blockers are usually the first line for treatment of AF regardless of it being for a rhythm or rate control strategy. We may also use them in combination with other anti-arrhythmic drugs such as: calcium channel blockers (diltiazem/verapamil) amiodarone.

Is there an alternative to flecainide? ›

Ranolazine as an Alternative Therapy to Flecainide for SCN5A V411M Long QT Syndrome Type 3 Patients.

Is flecainide well tolerated? ›

Flecainide is a well-tolerated medication, even at 12 months, with very minor adverse effects.

Which is safer flecainide or amiodarone? ›

Flecainide is more effective and safer than other AADs for the acute conversion of patients in AF.

Does flecainide damage liver? ›

Liver injury due to flecainide is rare and usually mild. Cases of prolonged jaundice, but no reports of acute liver failure, chronic hepatitis or vanishing bile duct syndrome attributed to flecainide, have been published.


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6. 심방세동 동율동 조절: 플레카이니드(flecainide), 프로파페논(propafenone), 필시카이니드(Pilsicainide)
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