Rizatriptan (oral) side effects (2023)

Description and brand names

Drug information provided by:IBM Micromedex

american brand

  1. maxalt
  2. Maxalt-MLT


Rizatriptan is used to treat acute migraine headaches in adults and children aged 6 years and over. It is not used to prevent migraines and it is not used for cluster headaches. Rizatriptan works in the brain to relieve migraine pain. It belongs to a group of medicines called triptans.

Many people find that their headaches go away completely after taking rizatriptan. Other people find that their headaches are much less painful and that they can return to their normal activities, even if their headaches do not go away completely. Rizatriptan generally relieves other symptoms that occur along with a migraine, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.

Rizatriptan is not a common pain reliever. It will not relieve any type of pain other than migraine. This medication is usually used for people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers.

Rizatriptan has caused serious side effects in some people, especially those with heart or blood vessel disease. Be sure to discuss with your doctor the risks of using this medication, as well as the benefits it may bring.

This medicine is only available with a prescription.

This product is available in the following dosage forms:

  • Junta
  • Compressed, Disintegrating

Before using

When deciding to use a drug, the risks of taking it must be weighed against the good it will do. This is a decision that you and your doctor will make. For this drug, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicine. Also tell your healthcare professional if you have any other allergies, such as food, dyes, preservatives, or animals. For over-the-counter products, read the label or package ingredients carefully.


Appropriate studies on the relationship of age to the effects of rizatriptan in children less than 6 years of age have not been performed. Safety and efficacy have not been established.

(Video) đź’ŠWhat is RIZATRIPTAN (Maxalt)?. Side effects, dosage and warnings of Rizatriptan (MAXALT)đź’Š


Appropriate studies to date have not demonstrated specific geriatric problems that would limit the usefulness of rizatriptan in the elderly. However, elderly patients are more prone to age-related high blood pressure and heart problems, which may require caution and dose adjustment for patients receiving rizatriptan.


There are no adequate studies in women to determine the infant risk of using this medicine while breastfeeding. Weigh the potential benefits against the potential risks before taking this medicine while breastfeeding.

Drug interactions

While certain drugs should not be used together, in other cases two different drugs can be used together even if an interaction occurs. In these cases, your doctor may want to change the dose or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions have been selected based on their potential significance and are not necessarily exhaustive.

The use of this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medicine or change some of the other medicines you take.

  • almotriptano
  • bromocriptine
  • dihydroergotamine
  • electricity
  • Mesilatos Ergoloides
  • Ergonovina
  • Ergotamine
  • frovatriptan
  • isocarboxazid
  • linezolid
  • Methylene blue
  • Methylergonovina
  • Metisergida
  • naratriptán
  • Fenelzina
  • Procarbazina
  • sumatriptano
  • tranylcypromine
  • Zolmitriptan

The use of this medicine with any of the following medicines is generally not recommended, but may be necessary in some cases. If both drugs are prescribed together, your doctor may change the dose or how often you use one or both drugs.

  • alfentanilo
  • amitriptyline
  • Amphetamine
  • benzhidrocodona
  • Benzfetamina
  • buprenorphine
  • bupropion
  • butorfanol
  • Citalopram
  • Codeine
  • desvenlafaxine
  • dextroanfetamina
  • dextrometorfano
  • dihydrocodeine
  • dolasetron
  • Duloxetine
  • escitalopram
  • fenfluramina
  • fentanyl
  • fluoxetine
  • fluvoxamina
  • granisetrona
  • hydrocodone
  • hydromorphone
  • lasmiditano
  • levomilnacipran
  • levorfanol
  • Lisdexanfetamina
  • Lithium
  • for Lorcaser
  • Meperidina
  • metaxalone
  • Methadone
  • methamphetamine
  • milnacipran
  • mirtazapine
  • Morphine
  • Morphine Sulfate Liposome
  • nalbuphine
  • nefazodon
  • ondansetron
  • oxicodona
  • oxymorphone
  • palonosetron
  • paroxetine
  • pentazocine
  • reboxetine
  • remifentanil
  • sertraline
  • sibutramine
  • Grass of San Juan
  • sufentanilo
  • Tapentadol
  • tramadol
  • trazodone
  • venlafaxine
  • Vilazodona
  • vortioxetine
  • Ziprasidone

Using this medication with any of the following medications may increase the risk of certain side effects, but using both medications may be the best treatment for you. If both drugs are prescribed together, your doctor may change the dose or how often you use one or both drugs.

  • propranolol

Other interactions

Certain medications should not be used at the time of eating or eating certain types of food, as interactions can occur. The use of alcohol or tobacco with certain medications can also cause interactions. Talk to your health care professional about using your medication with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical problems, especially:

  • Angina (chest pain) or
  • Basilar migraine (migraine with vision and hearing problems) or
  • Heart attack, history of o
  • Heart or blood vessel problems or
  • Hemiplegic migraine (migraine with some paralysis) or
  • Hypertension (high blood pressure), uncontrolled or
  • Ischemic bowel disease (intestines have low blood supply) or
  • peripheral vascular disease (clogged arteries) or
  • cerebrovascular accident, history or
  • Transient ischemic attack (TIA) or history of - Should not be used in patients with these conditions.
  • Coronary artery disease, family history of or
  • diabetes o
  • Hypercholesterolemia (high blood cholesterol) or
  • Hypertension (high blood pressure) or
  • obesity or
  • Raynaud's Syndrome - Use with caution. You may be at higher risk for certain side effects.
  • Phenylketonuria (PKU): The orally disintegrating tablet contains phenylalanine, which can make this condition worse.

appropriate use

Take this medication only as directed by your doctor. Do not take more, do not take more often, and do not take longer than your doctor has prescribed. Using too much rizatriptan can increase the chance of side effects.

Do not use this medication for headaches other than migraines. Talk to your doctor about what to do for regular headaches.

(Video) Rizatriptan (Maxalt) - Uses, Dosing, Side Effects

To relieve your migraine as quickly as possible, use rizatriptan as soon as the headache starts. Even if you have warning signs of an impending migraine (an aura), you should wait until the headache starts before using rizatriptan.

Lying down in a quiet, dark room for a while after using this medication may help relieve your migraines.

Ask your doctor ahead of time about any other medications you are taking if rizatriptan does not work. After taking the other medicine, see your doctor as soon as possible. Headaches that are not relieved by rizatriptan are sometimes caused by conditions that require other treatment.

If you feel much better after a dose of rizatriptan, but your headache returns or gets worse after a while, adults can use an additional dose of rizatriptan 2 hours after the first dose. Do not use more than 2 servings in a 24 hour period. Do not use this medicine for more than 10 days in a 30-day period unless your doctor tells you to.

Swallow the tablet whole with a glass of water. Do not crush, break or chew.

Keep the orally disintegrating tablet in the blister pack inside the outer foil pouch until you are ready to take the medication. Make sure your hands are dry and open the blister pack to remove the tablet. Place the tablet on the tongue and allow it to dissolve. You do not need to drink water to swallow the dissolved tablet.

This medication comes with the package insert. It is very important that you read and understand this information. Be sure to ask your doctor about anything you don't understand.


The dose of this medicine will be different for different patients. Follow your doctor's instructions or the instructions on the label. The following information only includes the average doses of this medication. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medication depend on the medical condition for which you are using it.

  • For oral dosage forms (tablets and orally disintegrating tablets):
    • For migraines:
      • Adults: Initially, 5 or 10 milligrams (mg) as a single dose. If the migraine returns after relief, another dose can be taken 2 hours after the last dose. Do not take more than 30mg in a 24 hour period.
      • Adolescents and children 6 years of age or older and weighing 40 kilograms (kg) or more: The dose is based on body weight and must be determined by your doctor. The dose is usually 10 mg per day. Do not take more than one dose in a 24 hour period.
      • Adolescents and children from 6 years of age and weighing less than 40 kg: the dose is based on body weight and must be determined by your doctor. The dose is usually 5 mg per day. Do not take more than one dose in a 24 hour period.
      • Children under 6 years of age: Use and dosage should be determined by your doctor.


Store the medication in a closed container at room temperature, away from heat, moisture, and direct light. Avoid freezing.

(Video) RIZATRIPTAN - Generic Name , Brand Names, How to use, Precautions, Side Effects

Keep out of the reach of children.

Do not store medications that are expired or no longer needed.

Ask your healthcare professional how to dispose of any unused medicine.


It is very important that your doctor monitor your or your child's progress at regular visits. This will allow your doctor to check that the medicine is working properly and to decide if you or your child should continue taking it.

You should not take this medicine if you or your child have used other triptans or ergot-type migraine medicines in the last 24 hours. Some examples of triptan medications are almotriptan (Axert™), eletriptan (Relpax®), frovatriptan (Frova®), naratriptan (Amerge®), sumatriptan (Imitrex®, Treximet®), and zolmitriptan (Zomig®). Some examples of ergot-type medications are dihydroergotamine (D.H.E. 45®, Migranal®), ergotamine (Bellergal®, Cafergot®, Ergomar®, or Wigraine®), and methysergide (Sansert®). Do not take this medication within 2 weeks of taking an MAO inhibitor such as Eldepryl®, Marplan®, Nardil®, or Parnate®.

Check with your doctor if you or your child have used this medication and your migraine has not gone away, or if your migraine has worsened or started to occur more frequently.

This medicine may increase your risk of having an abnormal heart rhythm, heart attack, angina, or stroke. This is more likely to happen if you or a family member already has heart disease, if you have diabetes, high blood pressure, high cholesterol, if you smoke, if you are a man over the age of 40, or if you are a woman and have gone through menopause. Call your doctor right away if you have any symptoms of a heart problem, such as chest pain or discomfort; irregular heartbeat; nausea or vomiting; pain or discomfort in the shoulders, arms, jaw, back, or neck; shortness of breath; or sweating. Call your doctor right away if you have any symptoms of a stroke, such as confusion; difficulty speaking; double vision; Headaches; inability to move arms, legs, or facial muscles; inability to speak; or speak slowly.

Check with your doctor right away if you or your child experience tightness in the chest, jaw, or neck after taking this medicine. Also, tell your doctor if you have sudden or severe abdominal or stomach pain or bloody diarrhea after using this medicine.

Consult your doctor immediately if you experience blurred vision, difficulty reading, or any other vision changes while you or your child are using this medicine. Your doctor may want you to have an eye exam (ophthalmologist).

Using rizatriptan alone or in combination with other migraine medicines for 10 or more days a month may cause a worsening of the headache. You can keep a headache diary to record the frequency of headaches and drug use.


Make sure your doctor knows about all the other medicines you are using. Rizatriptan can cause a serious condition called serotonin syndrome when it is taken with some medications. This includes medications to treat depression such as citalopram (Celexa®), duloxetine (Cymbalta®), escitalopram (Lexapro®), fluoxetine (Prozac®, Sarafem®, or Symbyax®), fluvoxamine (Luvox®), olanzapine (Zyprexa®), paroxetine (Paxil®), sertraline (Zoloft®), or venlafaxine (Effexor®). Check with your doctor right away if you or your child have agitation; confusion; diarrhea; excitement when speaking that is not normal; fever; hyperactive reflexes; poor coordination; concern; tremors; perspiration; tremors or tremors that you cannot control; or contraction. These could be symptoms of serotonin syndrome.

Drinking alcohol can make headaches worse or cause new headaches. People who suffer from severe headaches should probably avoid alcoholic beverages, especially during a headache.

Some people feel dizzy or sleepy during or after a migraine headache, or after taking rizatriptan for migraine relief. While you are feeling dizzy or drowsy, do not drive, use machinery, or do anything that could be dangerous if you are dizzy or not alert.

Do not take other medicines unless you discuss it with your doctor. This includes prescription and over-the-counter (OTC) medicines and herbal or vitamin supplements.

Collateral damage

Along with its necessary effects, a drug can cause some unwanted effects. While not all of these side effects can occur, if they do, they may require medical attention.

Check with your doctor right away if you experience any of the following side effects:

More common

  1. Chest pain
  2. heaviness, tightness, or pressure in the chest and/or neck
  3. racing heartbeat
  4. burning sensation, warmth, warmth, numbness, tightness, or tingling
  5. shortness of breath

less common

  1. Burning, tingling, itching, numbness, tingling, "pins and needles" or tingling sensation
  2. increased heart rate
  3. cardiac arrhythmia
  4. pain, tightness, or pressure in the neck, jaw, or throat
  5. slow heartbeat

There may be some side effects that usually do not require medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your healthcare professional will be able to tell you about ways to prevent or reduce some of these side effects. Check with your healthcare professional if any of the following side effects continue or are bothersome, or if you have any questions about them:

More common

  1. Dizziness
  2. dry mouth
  3. Hot flushes
  4. lack or loss of strength
  5. nausea or vomiting
  6. drowsiness or unusual drowsiness
  7. unusual tiredness or weakness

less common

  1. Agitation
  2. anxiety
  3. blurry vision
  4. shaking chills
  5. confusion
  6. cold
  7. depression
  8. diarrhea
  9. difficulty to swallow
  10. dry eyes
  11. eye irritation
  12. sensation of constant movement of oneself or surroundings
  13. gas
  14. headache
  15. Asia
  16. heat sensitivity
  17. inability to sleep
  18. increased sweating
  19. rise from seat
  20. irritability
  21. skin itch
  22. muscle or joint stiffness, tightness, or stiffness
  23. muscle pain or spasms
  24. ringing or ringing in the ears
  25. sudden and large increase in the frequency or amount of urine
  26. tremor of hands or feet
  27. unusual feeling of well-being
  28. sensations of cold or heat

Other side effects not listed may also occur in some patients. If you notice any other effects, consult your healthcare professional.

Call your doctor for medical advice on side effects. You can report side effects to the FDA by calling 1-800-FDA-1088.

Parts of this document were last updated: February 1, 2023

(Video) The Migraine Guy - Triptans (Maxalt)

Original article:https://www.mayoclinic.org/drugs-supplements/rizatriptan-oral-route/side-effects/DRG-20065868

Copyright © 2023 IBM Watson Health. All rights reserved. The information is for the exclusive use of the end user and may not be sold, redistributed or used for commercial purposes.



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