Sertraline 50 mg Pill (2023)

"sertraline" as active ingredient

Introduction Sertraline (as hydrochloride)

Sertraline belongs to theserotonin reuptake inhibitors, anySSRIs.
Regulates the amount of serotonin in the brain.

The very substance of this body plays a role in emotions and moods. SSRIs improve mood and reduce anxiety.

doctors prescribedepressionand withanxiety disorders, associal phobia, compulsive disorder,Panic Syndromeempost traumatic stress disorder.
It is also used in certainmenstrual complaints(premenstrual syndrome), in certain speciescut,beeleavesand withsexual disorders(premature ejaculation).

business information

sertralinehas been on the international market since 1990. It is available by prescription under the brand name Zoloft and as unbranded sertraline tablets and a concentrate for oral solution.

How should I use sertraline (as hydrochloride)?

Check the pharmacy label for the correct dosage.

(Video) Sertraline 50 mg | Sertraline tablet | daxid 50 mg | Sertraline uses | sertraline

  • pills: Take with half a glass of water.
  • drunk: Measure the prescribed amount of drink with the pipette provided and mix it into a glass of water or a sweet and sour drink such as lemon or lime lemonade or orange juice. Then drink it immediately. Always drink the diluted drink.

It does not matter what time of day you take this medicine. If the sedative effect bothers you a lot, take it at night before going to bed. If you suffer from a lot of restlessness and find it difficult to fall asleep, then it is better to take it in the morning.

How much time?

  • Depression.If the medication doesn't work after ten weeks, it probably doesn't make sense to continue. Talk to your doctor about this. After the complaints improve, you should generally continue to use it for six months. Then you have less chance of the depression coming back.
  • Feelings of anxiety and tension.If the medication doesn't work after three months, it probably doesn't make sense to continue. Talk to your doctor about this. After the complaints improve, it is usually necessary to continue using it for a year.
  • Social phobia.If the medication is still not working after three months, it probably makes no sense to continue. Talk to your doctor about this. After the complaints improve, you should generally continue to use it for another year.
  • compulsive disorder. If the medication is still not working after three months, it probably makes no sense to continue. Talk to your doctor about this. If it works well, you'll usually have to keep using it for several years.
  • Panic Syndrome. If the medication is still not working after six weeks, it probably doesn't make sense to continue. Talk to your doctor about this. After the complaints improve, you should generally continue to use it for another year.
  • Post-traumatic stress disorder.If the medication is still not working after three months, it probably makes no sense to continue. Talk to your doctor about this. After the complaints improve, you should generally continue to use it for at least a year.
  • premenstrual syndrome(SPM) . Your doctor may recommend that you use this medication every day or just for the two weeks before your period is due. If the drug has no effect after three menstrual periods, it probably makes no sense to continue taking it. Talk to your doctor about this.
  • Cut.Use this medication as long as the itch continues.
  • He.Use sertraline while you have symptoms. If you don't notice any improvement in your symptoms, talk to your doctor.
  • sexual disorders

If the medication is still not working after four weeks, it probably makes no sense to continue. Talk to your doctor about this.

Discuss any changes in your behavior or mood with your doctor during treatment. It is possible that you may not respond well or poorly to this medication and may benefit more from another medication.

What side effects should I watch out for?

In addition to the desired effect, this can cause side effects of drugs.

Side effects do not occur in everyone, but only in people who are sensitive to them.

Most side effects arein the first weekmore pronounced and then diminish or even disappear. They go away when you stop taking the medicine.

The main side effects are as follows.


  • gastrointestinal discomfortsuch as nausea, diarrhea, constipation, cramps and loss of appetite. This usually goes away within a few days after you get used to the medicine. You will experience less of these side effects if you take the medicine with certain foods. You can also ask your doctor to prescribe a dosage that will allow you to build up more slowly. any timea stomach or duodenal ulcertive, or any other serious stomach or intestinal disorder, such as stomach or intestinal bleeding? Then you are more likely to have side effects on your stomach and intestines. Check with your doctor. In addition to this medication, your doctor may also prescribe a stomach protector medication.
  • Dry mouth. As a result, cavities can develop earlier on the teeth. So brush and floss really well if you notice that your mouth is dry. If necessary, ask the dentist to check more often.
  • Temporarysexual disorderssuch as less desire to have sex, difficult erection and delayed ejaculation. These side effects go away when you stop taking the drug. Contact your doctor if you suffer from this.


  • Insomnia. If you suffer from this, always take the medicine in the morning.
  • somnolence, drowsiness and altered responsiveness. This is especially problematic with activities that require your attention, such as driving, climbing stairs, or monitoring a process at work. Do not participate in risky activities if you experience these side effects.
  • Headacheem dizziness. This mostly occurs at the start of treatment and goes away on its own.


  • oppression,confusion, anxiety and nervousness. See your doctor if this continues to bother you.
  • Blurred vision. See your doctor if this continues to bother you.
  • Sweating, yawning, shivering and shake.
  • Acne. In that case, consult your doctor. Very rarely, this is due to an allergic reaction to the drug and you must stop taking it.
  • Muscular contraction, and very rarely muscle cramps and muscle weakness.

Very rarely

  • weight change. Ask your doctor for a referral to a nutritionist if the weight change is too great and undesirable.
  • complaints from the heart, such as palpitations, chest pain, increased heart rate or, conversely, a slower heart rate. See your doctor if this bothers you too much.
  • cardiac arrhythmia. Sometimes you only notice this due to sudden dizziness or if you get lost for a while. Persons with the congenital form of prolonged QT interval cardiac arrhythmia are at particular risk of this. DO NOT take this medication if you have this congenital heart rhythm disorder.
  • Difficulty standing stillemconcern. People with Parkinson's disease in particular may suffer more from it. Consult your doctor if this happens, you may need to reduce your dose of sertraline.
  • mood swing, increased depressive thoughts and hostile feelings toward yourself or others. This can manifest itself in aggression, self-harm, or suicidal thoughts. Contact your doctor if feelings of depression increase or worsen. Young people under the age of 18 are more likely to experience these side effects. Therefore, doctors usually do not prescribe this drug.
  • hallucinations(seeing and hearing things that don't really exist). Then consult your doctor.
  • faster and longerto bleedin case of injury. You will also notice this in bruises and nosebleeds. See your doctor if this bothers you too much. This medication can cause bleeding problems. Therefore, tell your doctor that you are taking this medicine if you are going to have an operation.
  • hot flashes.
  • If youdiabetes mellitushave: your blood glucose may change because of this medicine. Therefore, check your blood glucose level more often.
  • hair loss. See your doctor if this bothers you too much.
  • people withepilepsythey are more likely to have an increase in seizures. Discuss this with your doctor.
  • euliver disease or inflammation of the pancreas. You may notice this by sudden, severe pain in your upper abdomen, a tender, swollen abdomen, or yellowing of the whites of your eyes or skin. In case of these complaints, inform your doctor.
  • hypersensitivityfor this drug. for this drug. You can notice this by a rash, itching and hives. See your doctor if you experience these symptoms. In rare cases, allergies can cause fever, swollen lips, tongue or face, or hypersensitivity to sunlight. Stop using it immediately and consult your doctor. If you are allergic, you should not use this medicine in the future. Tell your pharmacist that you are hypersensitive to sertraline. Pharmacy staff can make sure you don't get the medicine again.
  • Dizzinessespecially when getting up from bed or a chair. This usually resolves within a few days or weeks. If you feel dizzy, don't get out of bed or chair too quickly. It is better to lie down and raise your legs, for example, on a pillow.

Consult your doctor if any of the above side effects are too much for you or if you experience any other side effects that you are concerned about.

(Video) How and When to take Zoloft (Sertraline) | What Patients Need to Know

explain the frequencies

Regularly: in more than 30 out of 100 people
Sometimes: in 10 to 30 in 100 people
Seldom: affects 1 to 10 in 100 people
Very rarely: in less than 1 in 100 people

Does sertraline (as hydrochloride) interact with other medications?

This medicine interacts with other medicines. The text below lists only the active substances in these drugs, not the brands. You can check whether your medicine contains one of these active substances in the leaflet under the heading 'composition'.

The drugs with which the main interactions occur are as follows.

  • Other drugs that reduce responsiveness. These drugs usually have a number on the package.yellow warning stickertrapped The effects on, for example, the ability to react and the ability to coordinate are mutually reinforcing. Do not drive if you are taking any other medication that affects reaction time in addition to sertraline.
  • anti-inflammatory painkillerssuch as ibuprofen, diclofenac, aspirin, naproxen and celecoxib. These medications can cause stomach side effects, such as stomach bleeding. Concomitant use of sertraline increases the risk of these side effects. Therefore, it is preferable to use paracetamol as an analgesic. It doesn't have that inconvenience. Be extremely vigilant if you need to take sertraline along with an anti-inflammatory pain reliever, and consult your doctor if you experience an upset stomach. Usually, the doctor advises using a stomach protector to avoid stomach discomfort. Check with your doctor if this is necessary for you.
  • Ofanticoagulant drugs acenocumarolemphenprocoumon. Sertraline may potentiate the anticoagulant effect. Contact the Thrombosis Service if you start using sertraline, change your dose or stop using it.
  • the plastic pillchlorthalidone, chlorothiazide, hydrochlorothiazide, epithizide and indapamide. If you use one of these medicines together with sertraline, you are at increased risk of having a lack of sodium in your blood in the first few weeks. This can be mainly due to fluid loss such as vomiting, diarrhea, fever and heat. You will notice this by sudden severe fatigue, drowsiness, slurred speech, decreased appetite, vomiting and diarrhea. Then notify your doctor immediately.
  • tamoxifen, used in certain forms of breast cancer. Sertraline may reduce the effect of tamoxifen. Check with your doctor. You can switch to another medicine.
  • clozapinea medicine for delusions and hallucinations (antipsychotic). Sertraline may increase the amount of clozapine in the blood and therefore increase the side effects of clozapine. Contact your doctor. They may prescribe a different SSRI.
  • pimozida, a medicine against delusions and hallucinations (antipsychotic). When combined with pimozide, you have an increased risk of heart rhythm disturbances. You may feel suddenly dizzy or lose consciousness for a short time. DO NOT use with pimozide unless your doctor decides it is unavoidable.
  • metronidazole,an antibiotic anddisulfiram, used against alcohol addiction. You shouldn't use alcohol with these medications, as it can make you very sick. Are you taking the oral solution with sertraline? Then talk to your doctor. The drink contains a small amount of alcohol.
  • SomeHIV medications. Ask your pharmacist which drugs he is referring to.

When combined with the following medicines, there is a small risk of serious side effects, whichserotonin.

  • analgesicsfentanyl,oxicodona,pethidineemtramadol.
  • the antibioticlinezolid.
  • depression medicationsof the tricyclic group amitriptyline, clomipramine, dosulepin, doxepin, imipramine, maprotiline and nortriptyline.

Discuss these medications with your doctor. Your doctor may prescribe another medicine that does not pose this risk. If you need to use the combination, watch out for symptoms such as tremors, tremors, the urge to move, muscle spasms, agitation, confusion, fear, fever, sweating, increased heart rate and decreased consciousness.

Serotonin syndrome is not always associated with these symptoms. Some of these side effects may also be part of your illness or may go away on their own. If in doubt consult your doctor as this is a serious side effect.
Also inform people close to you about these side effects, as you may not always notice them due to confusion and reduced consciousness. They can then contact their GP.

The risk of this side effect is relatively high with the following medications.

  • Selegiline and rasagiline, medicines forParkinson disease.
  • phenelzine, tranylcypromine and moclobemide,depression medications.

You should not use these drugs together with sertraline. Even if you have already stopped taking sertraline, it will take a week before you can safely use these drugs. Check with your doctor. Instead, it takes two weeks before you can start sertraline after stopping these medications. You can start taking moclobemide as soon as one day after stopping sertraline.

Not sure if any of the above compensations interest you? Contact your pharmacist or doctor.

If I take sertraline (as hydrochloride), can I...

This medication can cause side effects such as drowsiness, fatigue, dizziness, confusion, anxiety, nervousness, and blurred vision. Does it affect you? Then you are not allowed to drive. It can be dangerous to drive while you have these side effects. These side effects mostly occur in the first few days of use. Even if the dose is increased, you may experience (additional) side effects.

N.B:Depression or severe panic attacks could also be a reason why you are not allowed to drive. Talk to your doctor if this applies to you. Want more information on how to drive in certain conditions? then see on the websiteCBR.

For more general information, the topic 'drugs in traffic' to read. In this topic you can read, for example, what the law says about drugs in transit. You'll also find tips to keep in mind if you ever want to drive again.

drinking alcohol?
Alcohol increases the sedative effect of this drug. Even if you don't notice it anymore because you got used to sertraline, alcohol use can make you very sleepy. Therefore, limit the use of alcohol and prefer not to drink.

(Video) My Experience Taking Zoloft for Anxiety and Depression / 6 Months Later / Side Effects, Dose, Etc.

eat everything?
There are no restrictions for this with this drug.

Can I take sertraline (as hydrochloride) if I am pregnant or breastfeeding?

the pregnancy
Sertraline oral solution contains a small amount of alcohol. Therefore, the drink should not be used during pregnancy.

When used against depression.
Discuss the severity of your condition with the risk of this medication to your child with your doctor. If this drug is used during pregnancy, the child may experience withdrawal symptoms and other side effects after birth. But depressive symptoms can also be harmful for both mother and child. So talk to your doctor about the pros and cons.

  • Did you have a wish as a child? Please consult your doctor first. Both men and women may be less fertile due to this medication. As a result, the woman is less likely to become pregnant.
  • Are you already using this medication and became pregnant? So talk to your doctor right away. It is generally not recommended to stop this medication. The recurrence of depressive symptoms can be harmful for mother and child.

in other applications
Discuss the severity of your condition with the risk of this medication to your child with your doctor. If this drug is used during pregnancy, the child may experience withdrawal symptoms and other side effects after birth.

Did you have a wish as a child? Please consult your doctor first. Both men and women may be less fertile due to this medicine. As a result, the woman is less likely to become pregnant.

If you want to breast-feed, talk to your doctor or pharmacist. This medication passes into breast milk in small amounts. Therefore, it may cause side effects in the child. You will notice why your baby is restless, cries a lot, drinks poorly, is sleepy or has diarrhea.

If your doctor thinks you may breastfeed, be on the lookout for these symptoms. If these symptoms occur, contact your doctor.

What should I do if I miss a dose?

It is important that you continue to take this medicine consistently. If you miss a dose, take it as soon as possible.16 hours. If there are less than 8 hours until the next dose, skip the missed dose. Do not take a double dose.

(Video) Zoloft (Sertraline): What are the Side Effects? Watch Before You Start!

Can I stop taking sertraline (as hydrochloride)?

Preferably taper off slowly over a four week period. After stopping suddenly, some people experience anxiety, dizziness, lightheadedness, headache, nausea, and sweating. These symptoms usually don't appear until one to four days after a sudden interruption and disappear within three weeks.

Not everyone suffers from withdrawal symptoms. So see how you react if you reduce the dose slightly. If it doesn't bother you, you can decrease it faster. Ask your doctor for advice about this.

If you are taking this medicine for adepression: Please note that the effect of sertraline peaks after about six weeks and that you should continue taking the drug for at least another six months. If stopped early, the depression is more likely to return.

If you are using this medication for depression, it is usually discontinued for an extended period of time to prevent depression symptoms from returning.

If you use this medicine againstPanic Syndromeoffeelings of anxietyit often has to taper off gradually over several months. This way you avoid complaints coming back.


This text was prepared byKNMP Drug Information Center. This text is based on the package leaflet of the described drug and other scientific sources. Officially registered data for this drug with the Drug Evaluation Board can be found Whilst the utmost care has been taken in preparing the text, the KNMP cannot be held responsible for any damages that may result from any inaccuracies in this text.

Page requested on 03/18/2023

Last revision: 02-03-2017

(Video) Sertraline - FIVE Side Effects for first 2 weeks of Zoloft

GPK: 92991 (13)

  • be careful with alcohol
  • can reduce responsiveness
  • sertraline
  • cellulose, microcrystalline
  • Calcium Monohydrogen Phosphate 2-Water
  • hyprolose
  • carboximetilzetmeel natrio
  • magnesium stearate
  • in hypromellose
  • to speak
  • titanium dioxide

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