Sumatriptan (subcutaneous use) side effects (2023)

Brand Description and Name

Drug information provided by:IBM Micromedex

american brand

1. shortness of breath
2. Imitrex
3. Imitrex Stat dose refill
4. Sumavel DosePro
5. Zembrace Symtouch

descriptions

Sumatriptan injection is used to treat acute migraine attacks and cluster headaches in adults. Sumatriptan works in the brain to relieve migraine pain. It belongs to a group of medicines called triptans.

Many people find that their headaches go away completely after using sumatriptan. Other people find that their headaches are much less painful and that they are able to return to their normal activities even if their headaches have not gone away completely. Sumatriptan often relieves other symptoms that accompany a migraine, such as nausea, vomiting, and sensitivity to light and noise.

Sumatriptan is not an ordinary pain reliever. It does not relieve pain other than migraines. This medicine is usually used in people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers.

Sumatriptan has caused serious side effects in some people, particularly those with heart or blood vessel disease. Be sure to discuss the risks of using this drug, as well as its benefits, with your doctor.

This medicine can only be obtained with a prescription.

This product is available in the following dosage forms:

• Solution
• kit

Before use

When deciding on a drug, the risks of taking it must be weighed against the benefits. This is a decision you and your doctor will make. Things to note about this drug:

allergies

Tell your doctor if you've ever had any unusual or allergic reaction to this medicine or any other medicine. Also, tell your doctor if you have any other type of allergy, such as B. against food, dyes, preservatives or animals. For over-the-counter products, carefully read the ingredient label or packaging.

paediatrics

No adequate studies have been conducted on the association between age and the effects of sumatriptan injection in children and adolescents. The use of Imitrex® in children is not recommended. Safety and effectiveness have not been established.

geriatric

Sumatriptan injection is not recommended for use in elderly patients with kidney problems, heart or blood vessel disease, or high blood pressure, and it should not be used by elderly patients with liver problems.

breastfeeding

There are insufficient studies in women to determine the risk to infants of using this drug while breastfeeding. Weigh the potential benefits against the potential risks before using this drug while breastfeeding.

Interactions with other drugs

While certain medications should not be used together, in other cases two different medications can be used together even if an interaction occurs. In these cases your doctor may change the dose or other precautions may be needed. If you're taking this medication, it's especially important for your doctor to know if you're taking any of the medications listed below. The following interactions have been selected for their potential importance and are not necessarily comprehensive.

The use of this medication with any of the following medications is not recommended. Your doctor may decide not to treat you with this medication or to change some of the other medications you are taking.

• Almotriptano
• Bromocriptine
• Dihydroergotamin
• Eletriptan
• Mesilatos Ergoloides
• Ergonovina
• Ergotamine
• Frovatriptan
• Furazolidona
• Iproniazid
• Isocarboxazid
• Linezolid
• Methylenblau
• Methylergonovina
• Metisergida
• moclobemida
• Naratriptan
• Nialamida
• fennel
• Procarbazina
• Rasagilina
• Rizatriptan
• Safinamida
• Selegilina
• Tranylcypromin
• Zolmitriptan

Using this medication with any of the following medications is generally not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or frequency of use of one or both medicines.

• Alfentanil
• Amineptin
• Amitriptyline
• Amitriptylinoxid
• Amoxapin
• amphetamine
• benzhidrocodona
• Benzfetamina
• Buprenorphin
• Bupropion
• Butorfanol
• Citalopram
• Clomipramina
• Codeine
• Desipramine
• Desvenlafaxine
• Dexfenfluramin
• Dextroanfetamina
• Dextrometorfano
• Dibenzepina
• Dihydrocodein
• Dolasetron
• Doxepina
• Duloxetine
• Escitalopram
• Fenfluramina
• Fentanyl
• fluoxetine
• Fluvoxamin
• Granisetrona
• Hydrocodon
• Hydromorphon
• Imipramine
• lasmiditano
• Levomilnacipran
• Levorfanol
• Lisdexanfetamina
• Lithium
• Lofepramina
• von Lorcaser
• Melitraceno
• Meperidina
• Metaxalone
• Methamphetamine
• Milnacipran
• Mirtazapine
• morphine
• Morphinsulfat-Liposom
• nalbuphine
• Nefazodon
• Nortriptilina
• ondansetron
• Opipramol
• Oxicodona
• Oxymorphon
• Palonosetron
• Paroxetine
• Pentazocin
• Protriptilina
• Reboxetin
• Remifentanil
• Sertraline
• Sibutramine
• Johannis herbs
• Sufentanil
• Tapentadol
• Tianeptin
• Tramadol
• Trazodon
• Trimipramine
• Venlafaxine
• Vilazodona
• Vortioxetin
• Ziprasidone

Other Interactions

Certain medications should not be used at the time of eating or eating certain types of food because interactions can occur. The consumption of alcohol or tobacco with certain medications can also lead to interactions. Discuss with your doctor about taking your medication with food, alcohol or tobacco.

Other medical problems

The presence of other medical problems may interfere with the use of this medication. Be sure to tell your doctor if you have any other medical problems, especially:

• angina (chest pain)
• arrhythmia (heart rhythm disturbance)
• Basil migraine (migraine with vision and hearing problems), anamnesis or
• heart attack, history of or
• heart or blood vessel disease or
• Hemiplegic migraine (migraine with some paralysis), history or
• Hypertension (high blood pressure), uncontrolled or
• Ischemic bowel disease (the gut has a low blood supply) or
• Severe liver disease or
• Peripheral vascular disease (clogged arteries) or
• stroke history
• Transient ischemic attack (TIA), history or
• Wolff-Parkinson-White Syndrome (arrhythmia) - Must not be used in patients with these conditions.

• bleeding problems or
• Cardiac arrhythmias (e.g. ventricular fibrillation, ventricular tachycardia) or
• Seizures or epilepsy, history of or
• Stomach or intestinal bleeding - use with caution. It can make these conditions worse.

• Coronary heart disease, medical history
• diabetes or
• Hypercholesterolaemia (high blood cholesterol) or
• hypertension (high blood pressure) or
• obesity or
• Raynaud's Syndrome - Use with caution. You may be at increased risk of more serious side effects.

correct use

Do not use this medication for migraines or cluster headaches, which are different from your usual headaches. Instead, consult your doctor.

To relieve your migraines as quickly as possible, use this medication as soon as the headache starts. Even if you get warning signs of an impending migraine (an aura), you should wait until the headache starts before using sumatriptan.

Ask your doctor ahead of time about other medications you might be taking if sumatriptan isn't working. Contact your doctor as soon as possible after using the other medicine. Headaches that are not relieved by sumatriptan are sometimes caused by medical conditions that require different treatment.

If you feel much better after one dose of Sumatriptan but your headache comes back after a while or gets worse, wait at least 1 hour before taking another dose. However, use this medication only as directed by your doctor. Do not use more or more often than recommended. Using too much sumatriptan can increase the chance of side effects. Do not use more than 2 servings in 24 hours.

This drug is given as an injection under the skin (usually in the abdomen, thighs, or upper arms). Sometimes sumatriptan injection can be administered at home for patients who do not need to be in a hospital or clinic. If you use this medicine at home, your doctor or nurse will show you how to prepare and inject the medicine. Make sure you understand how to use the medicine.

When you use this medicine at home, you will be shown the areas of the body where this injection can be given. Use a different area of ​​the body for each attempt. Track where you take each shot to make sure you're rotating body areas. This helps prevent skin problems.

This medicine is available in 3 forms. You can use a single-dose vial, pre-filled syringe or pre-filled auto-injector.

Do not use the medicine if it is dark or cloudy.

After you have finished injecting the medication, be sure to follow the precautions in the patient information sheet for the safe disposal of the empty cartridge and needle. Always return the empty cartridge and needle to the container before disposing of them. Do not throw away the auto-injector unit as refill packs are available.

This medicine is included in the package leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

dosage

The dose of this drug will be different for different patients. Follow your doctor's or label directions. The information below contains only the average doses of this drug. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. Also, the number of doses you take each day, the time between doses, and how long you take the drug will depend on the condition you are using the drug for.

• For injection dosage form:
  • For migraines or cluster headaches:
    • Adult-
      • Alsuma™, Imitrex® and Sumavel®: 4 or 6 milligrams (mg) injected under the skin. If the headache returns after relief, another dose can be injected after 1 hour. Do not use more than 2 doses of 6 mg or 3 doses of 4 mg in any 24 hour period.
      • Zembrace™ Symtouch™: 3 milligrams (mg) injected under the skin. If the headache returns after relief, another dose can be injected after 1 hour. Do not use more than 4 doses of 3 mg in any 24 hour period.
    • Children - The use and dose must be determined by your doctor.

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Store the medicine in a closed container at room temperature away from heat, moisture and direct light. avoid freezing.

Keep away from children.

Do not keep medicines that have expired or are no longer needed.

Ask your doctor how to throw away any unused medicine.

Dispose of used syringes or auto-injectors in a rigid, closed container that needles cannot penetrate. Keep this container away from children and pets.

Precautions

It is very important that your doctor checks your progress at regular visits. This way your doctor can check that the medicine is working properly and decide whether you should continue to use it and check for any unwanted effects.

Contact your doctor if you have used this medication and have not had good relief. Also, check with your doctor to determine if your migraines or cluster headaches are worse or more frequent than they were before you started taking this medication.

You should not receive this medication if you are using or have used an MAO inhibitor (MAOI) such as phenelzine (Nardil®) or tranylcypromine (Parnate®) within the past 2 weeks. Do not use this medication if you have previously used other triptan medications for migraines. Some examples of triptan medications are almotriptan (Axert®), eletriptan (Relpax®), naratriptan (Amerge®), or zolmitriptan (Zomig®). Some examples of ergot-type drugs are dihydroergotamine (D.H.E. 45®, Migranal®), ergotamine (Bellergal®, Cafergot®, Ergomar®, Wigraine®), or methysergide (Sansert®).

Contact your doctor if you have been using sumatriptan and your migraines got worse or came more often.

The needle cap of the Imitrex® pre-filled syringe contains dried natural rubber (a derivative of latex) which may cause allergic reactions in people sensitive to latex. Tell your doctor if you have a latex allergy before receiving this medication.

This drug may increase your risk of abnormal heart rhythms, heart attack, angina, or stroke. This is more likely if you or a family member already have heart disease, if you have diabetes or high blood pressure, or if you smoke. Call your doctor right away if you have symptoms of a heart problem, such as B. chest pain or discomfort, irregular heartbeat, nausea or vomiting, pain or discomfort in the shoulders, arms, jaw, back or neck, or sweating. Call your doctor at once if you experience stroke symptoms such as confusion, difficulty speaking, double vision, headache, inability to move your arms, legs, or facial muscles, inability to speak, or slow speech.

Talk to your doctor right away if you experience chest discomfort, jaw tightness, or neck tightness after using this medication. Also, tell your doctor if you have sudden or severe abdominal or stomach pain, or bloody diarrhea after using this medication.

Contact your doctor immediately if you experience blurred vision, difficulty reading, or other vision problems during or after treatment. Your doctor may ask you to have an eye exam (ophthalmologist).

Using sumatriptan alone or in combination with other migraine medications for 10 or more days per month can cause the headache to worsen. You can keep a headache diary to record headache frequency and medication use.

Make sure your doctor knows about all other medications you are taking. Sumatriptan can cause a serious condition called serotonin syndrome when used with some medications. These include, in particular, drugs used to treat depression such as citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, olanzapine, paroxetine, sertraline, venlafaxine, Celexa®, Cymbalta®, Effexor®, Lexapro®, Luvox®, Paxil®, Prozac®, Sarafem® , Symbyax® or Zoloft®. See your doctor right away if you experience agitation, confusion, diarrhea, agitation when speaking that is not normal, fever, overactive reflexes, poor coordination, restlessness, tremors, sweating, uncontrollable shaking or shaking, or convulsions. These could be symptoms of serotonin syndrome.

This drug can cause serious allergic reactions, including anaphylaxis and angioedema. These can be fatal and require immediate medical attention. The most serious signs of this reaction are very rapid or irregular breathing, shortness of breath, or fainting. Other signs may include changes in the color of the skin on the face, a very fast but irregular heartbeat or pulse, lumps on the skin and puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help immediately.

Alcohol consumption can make headaches worse or cause new headaches. People suffering from severe headaches should avoid alcoholic beverages, especially during the headache.

This medicine may make some people feel dizzy, sleepy, or less alert than they normally are. Do not drive or do anything else that might be dangerous until you know how this medicine affects you.

side effects

In addition to the necessary effects, a drug can have some undesirable effects. Although not all of these side effects may occur, they may require medical attention if they do occur.

Contact your doctor immediately if any of the following side effects occur:

less common

1. blurred vision
2. pain or discomfort in your chest
3. chills
4. confusion
5. labored or strained breathing
6. dizziness
7. Dizziness, fainting, or lightheaded when you get up suddenly from a lying or sitting position
8. fainting
9. fast, racing, or irregular heartbeat or pulse
10. Headache
11. nervousness
12. bang in the ears
13. Trembling in the legs, arms, hands, or feet
14. slow heartbeat
15. Sweat
16. feeling of tension in the head
17. tightness or pressure in the chest
18. shaking or trembling of hands or feet
19. unusual tiredness or weakness

Cru

1. Black stool and tar
2. blood in the urine
3. blood in the vomit
4. Burning when urinating
5. Cough
6. decreased urination
7. Skin depression
8. Diarrhea
9. dry mouth
10. feeling hot or hot
11. Fever
12. Reddening or flushing of the skin, especially on the face and neck
13. feeling generally unwell or sick
14. inability to move the eyes
15. Inability to move legs or arms
16. increase heart rate
17. increased blinking or twitching of the eyelid
18. increased sensitivity to pain
19. increased touch sensitivity
20. skin indentation
21. joint pain
22. Appetitverlust
23. muscle aches and pains
24. nausea
25. Pain in the groin or genitals
26. pallor of the skin
27. Pallor or coldness in the tips of the fingers and toes
28. paralysis on one side of the body
29. rapid breathing
30. runny nose
31. severe or persistent abdominal pain
32. sharp back pain just below the ribs
33. Tremble
34. sore throat
35. come from the tongue
36. deep eyes
37. Property
38. Tingling in hands and feet
39. Tingling or pain in your fingers or toes when exposed to cold
40. sleep disorders
41. Difficulty speaking or swallowing
42. uncontrolled twisting movements of the neck, trunk, arms or legs
43. unusual facial expressions
44. to throw up
45. wrinkled skin

unknown incidence

1. Agitation
2. Back, leg or stomach pain
3. bleeding gums
4. blood in the stool
5. bluish color of nails, lips, skin, palms, or nail beds
6. skin color changes
7. vision changes
8. decreased awareness or responsiveness
9. Depression
10. double vision
11. general swelling of the body
12. Headache, sudden, severe and persistent
13. high fever
14. hives or itching
15. hostility
16. inability to speak
17. irritability
18. large, hive-like swelling of the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
19. Loss of the ability to use or understand speech or language
20. Appetitverlust
21. loss of consciousness
22. vision loss
23. migraine
24. muscle cramps
25. noisy breathing
26. nosebleeds
27. hyperaktive Reflexe
28. Pain, tenderness, or swelling of the foot or leg
29. detect red spots on the skin
30. bad coordination
31. Swelling or swelling of the eyelids or around the eyes, face, lips, or tongue
32. rapid weight gain
33. rectal bleeding
34. Redness, pain or itching of the skin
35. restlessness
36. seizures
37. severe or sudden headache
38. severe drowsiness
39. slurred speech
40. Sores, ulcers, or white patches on the lips or inside the mouth
41. sores, welts, or blisters
42. abdominal pain and tenderness
43. swelling of the face, ankles, hands, feet or legs
44. swollen glands
45. Speaking or acting with excitement that you cannot control
46. temporary blindness
47. shake or shake
48. conclusion of contract
49. unexplained bleeding or bruising
50. unusual bleeding or bruising
51. unusual sleepiness, dullness, or sluggishness
52. exceptionally hot skin
53. Weakness in the arm or leg on one side of the body, sudden and severe
54. weight loss
55. yellowing of the eyes or skin

There may be some side effects that do not usually require medical attention. These side effects may go away during treatment as your body gets used to the medicine. Also, your doctor can tell you about ways to prevent or reduce some of these side effects. Contact your doctor if any of the following side effects persist or bother you, or if you have any questions about them:

more often

1. Bleeding, blistering, burning, cold, skin discolouration, pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, pain, stinging, swelling, tenderness, tingling, ulceration or heat at the injection site
2. burning or tingling
3. sleepiness
4. Feeling of constant movement of self or environment
5. hot feeling
6. Redness of the face, neck, arms and occasionally the upper chest
7. feel relaxed and calm
8. turning sensation
9. sleepiness

less common

1. Angst
2. bad, unusual, or unpleasant taste (after)
3. Burning, tingling, itching, numbness, tingling, tingling, or prickling sensation
4. change in color vision
5. change in taste
6. see bad at night
7. movement difficulties
8. Discomfort in the jaw, nasal cavity or throat
9. false or unusual well-being
10. feel weird
11. Asia
12. increased sensitivity of the eyes to sunlight
13. Joint pain, stiffness or swelling
14. mental confusion
15. muscle pain or cramps
16. neck pain or stiffness
17. red and sore eyes
18. upset stomach
19. swollen joints
20. teary eyes
21. Property
22. weakness

Cru

1. back pain
2. burping
3. Bloating or bloating
4. Changes in speech patterns and rhythms
5. cramps
6. dry vomit
7. excess air or gas in the stomach or intestines
8. extreme headquarters
9. profuse bleeding
10. hiccup
11. fome
12. elevation from the seat
13. Muscle cramp
14. muscle spasms or convulsions
15. dor
16. pass gas
17. decreased appetite
18. rhythmic movement of muscles
19. severe abdominal pain with nausea and vomiting
20. skin sensitivity

unknown incidence

1. deafness
2. Panic
3. severe sunburn

Some patients may also experience other side effects not listed. If you notice other effects, contact your doctor.

Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Portions of this document were last updated: February 1, 2023

Original article:https://www.mayoclinic.org/drugs-supplements/sumatriptan-subcutânea-route/side-effects/drg-20074378

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