Sumatriptan (subcutaneous use) side effects (2023)

Brand Description and Name

Drug information provided by:IBM Micromedex

american brand

  1. shortness of breath
  2. Imitrex
  3. Imitrex Stat dose refill
  4. Sumavel DosePro
  5. Zembrace Symtouch


Sumatriptan injection is used to treat acute migraine attacks and cluster headaches in adults. Sumatriptan works in the brain to relieve migraine pain. It belongs to a group of medicines called triptans.

Many people find that their headaches go away completely after using sumatriptan. Other people find that their headaches are much less painful and that they are able to return to their normal activities even if their headaches have not gone away completely. Sumatriptan often relieves other symptoms that accompany a migraine, such as nausea, vomiting, and sensitivity to light and noise.

Sumatriptan is not an ordinary pain reliever. It does not relieve pain other than migraines. This medicine is usually used in people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers.

Sumatriptan has caused serious side effects in some people, particularly those with heart or blood vessel disease. Be sure to discuss the risks of using this drug, as well as its benefits, with your doctor.

This medicine can only be obtained with a prescription.

This product is available in the following dosage forms:

  • Solution
  • kit

Before use

When deciding on a drug, the risks of taking it must be weighed against the benefits. This is a decision you and your doctor will make. Things to note about this drug:


Tell your doctor if you've ever had any unusual or allergic reaction to this medicine or any other medicine. Also, tell your doctor if you have any other type of allergy, such as B. against food, dyes, preservatives or animals. For over-the-counter products, carefully read the ingredient label or packaging.


No adequate studies have been conducted on the association between age and the effects of sumatriptan injection in children and adolescents. The use of Imitrex® in children is not recommended. Safety and effectiveness have not been established.


Sumatriptan injection is not recommended for use in elderly patients with kidney problems, heart or blood vessel disease, or high blood pressure, and it should not be used by elderly patients with liver problems.

(Video) Sumatriptan SIde Effects - Pharmacist's Experience


There are insufficient studies in women to determine the risk to infants of using this drug while breastfeeding. Weigh the potential benefits against the potential risks before using this drug while breastfeeding.

Interactions with other drugs

While certain medications should not be used together, in other cases two different medications can be used together even if an interaction occurs. In these cases your doctor may change the dose or other precautions may be needed. If you're taking this medication, it's especially important for your doctor to know if you're taking any of the medications listed below. The following interactions have been selected for their potential importance and are not necessarily comprehensive.

The use of this medication with any of the following medications is not recommended. Your doctor may decide not to treat you with this medication or to change some of the other medications you are taking.

  • Almotriptano
  • Bromocriptine
  • Dihydroergotamin
  • Eletriptan
  • Mesilatos Ergoloides
  • Ergonovina
  • Ergotamine
  • Frovatriptan
  • Furazolidona
  • Iproniazid
  • Isocarboxazid
  • Linezolid
  • Methylenblau
  • Methylergonovina
  • Metisergida
  • moclobemida
  • Naratriptan
  • Nialamida
  • fennel
  • Procarbazina
  • Rasagilina
  • Rizatriptan
  • Safinamida
  • Selegilina
  • Tranylcypromin
  • Zolmitriptan

Using this medication with any of the following medications is generally not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or frequency of use of one or both medicines.

  • Alfentanil
  • Amineptin
  • Amitriptyline
  • Amitriptylinoxid
  • Amoxapin
  • amphetamine
  • benzhidrocodona
  • Benzfetamina
  • Buprenorphin
  • Bupropion
  • Butorfanol
  • Citalopram
  • Clomipramina
  • Codeine
  • Desipramine
  • Desvenlafaxine
  • Dexfenfluramin
  • Dextroanfetamina
  • Dextrometorfano
  • Dibenzepina
  • Dihydrocodein
  • Dolasetron
  • Doxepina
  • Duloxetine
  • Escitalopram
  • Fenfluramina
  • Fentanyl
  • fluoxetine
  • Fluvoxamin
  • Granisetrona
  • Hydrocodon
  • Hydromorphon
  • Imipramine
  • lasmiditano
  • Levomilnacipran
  • Levorfanol
  • Lisdexanfetamina
  • Lithium
  • Lofepramina
  • von Lorcaser
  • Melitraceno
  • Meperidina
  • Metaxalone
  • Methamphetamine
  • Milnacipran
  • Mirtazapine
  • morphine
  • Morphinsulfat-Liposom
  • nalbuphine
  • Nefazodon
  • Nortriptilina
  • ondansetron
  • Opipramol
  • Oxicodona
  • Oxymorphon
  • Palonosetron
  • Paroxetine
  • Pentazocin
  • Protriptilina
  • Reboxetin
  • Remifentanil
  • Sertraline
  • Sibutramine
  • Johannis herbs
  • Sufentanil
  • Tapentadol
  • Tianeptin
  • Tramadol
  • Trazodon
  • Trimipramine
  • Venlafaxine
  • Vilazodona
  • Vortioxetin
  • Ziprasidone

Other Interactions

Certain medications should not be used at the time of eating or eating certain types of food because interactions can occur. The consumption of alcohol or tobacco with certain medications can also lead to interactions. Discuss with your doctor about taking your medication with food, alcohol or tobacco.

Other medical problems

The presence of other medical problems may interfere with the use of this medication. Be sure to tell your doctor if you have any other medical problems, especially:

  • angina (chest pain)
  • arrhythmia (heart rhythm disturbance)
  • Basil migraine (migraine with vision and hearing problems), anamnesis or
  • heart attack, history of or
  • heart or blood vessel disease or
  • Hemiplegic migraine (migraine with some paralysis), history or
  • Hypertension (high blood pressure), uncontrolled or
  • Ischemic bowel disease (the gut has a low blood supply) or
  • Severe liver disease or
  • Peripheral vascular disease (clogged arteries) or
  • stroke history
  • Transient ischemic attack (TIA), history or
  • Wolff-Parkinson-White Syndrome (arrhythmia) - Must not be used in patients with these conditions.
  • bleeding problems or
  • Cardiac arrhythmias (e.g. ventricular fibrillation, ventricular tachycardia) or
  • Seizures or epilepsy, history of or
  • Stomach or intestinal bleeding - use with caution. It can make these conditions worse.
  • Coronary heart disease, medical history
  • diabetes or
  • Hypercholesterolaemia (high blood cholesterol) or
  • hypertension (high blood pressure) or
  • obesity or
  • Raynaud's Syndrome - Use with caution. You may be at increased risk of more serious side effects.

correct use

Do not use this medication for migraines or cluster headaches, which are different from your usual headaches. Instead, consult your doctor.

To relieve your migraines as quickly as possible, use this medication as soon as the headache starts. Even if you get warning signs of an impending migraine (an aura), you should wait until the headache starts before using sumatriptan.

Ask your doctor ahead of time about other medications you might be taking if sumatriptan isn't working. Contact your doctor as soon as possible after using the other medicine. Headaches that are not relieved by sumatriptan are sometimes caused by medical conditions that require different treatment.

If you feel much better after one dose of Sumatriptan but your headache comes back after a while or gets worse, wait at least 1 hour before taking another dose. However, use this medication only as directed by your doctor. Do not use more or more often than recommended. Using too much sumatriptan can increase the chance of side effects. Do not use more than 2 servings in 24 hours.

This drug is given as an injection under the skin (usually in the abdomen, thighs, or upper arms). Sometimes sumatriptan injection can be administered at home for patients who do not need to be in a hospital or clinic. If you use this medicine at home, your doctor or nurse will show you how to prepare and inject the medicine. Make sure you understand how to use the medicine.

(Video) Subcutaneous delivery of sumatriptan in the treatment of migraine - Video abstract: 19171

When you use this medicine at home, you will be shown the areas of the body where this injection can be given. Use a different area of ​​the body for each attempt. Track where you take each shot to make sure you're rotating body areas. This helps prevent skin problems.

This medicine is available in 3 forms. You can use a single-dose vial, pre-filled syringe or pre-filled auto-injector.

Do not use the medicine if it is dark or cloudy.

After you have finished injecting the medication, be sure to follow the precautions in the patient information sheet for the safe disposal of the empty cartridge and needle. Always return the empty cartridge and needle to the container before disposing of them. Do not throw away the auto-injector unit as refill packs are available.

This medicine is included in the package leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.


The dose of this drug will be different for different patients. Follow your doctor's or label directions. The information below contains only the average doses of this drug. If your dose is different, do not change it unless your doctor tells you to.

The amount of medicine you take depends on the strength of the medicine. Also, the number of doses you take each day, the time between doses, and how long you take the drug will depend on the condition you are using the drug for.

  • For injection dosage form:
    • For migraines or cluster headaches:
      • Adult-
        • Alsumaâ„¢, Imitrex® and Sumavel®: 4 or 6 milligrams (mg) injected under the skin. If the headache returns after relief, another dose can be injected after 1 hour. Do not use more than 2 doses of 6 mg or 3 doses of 4 mg in any 24 hour period.
        • Zembraceâ„¢ Symtouchâ„¢: 3 milligrams (mg) injected under the skin. If the headache returns after relief, another dose can be injected after 1 hour. Do not use more than 4 doses of 3 mg in any 24 hour period.
      • Children - The use and dose must be determined by your doctor.

Save on computer

Store the medicine in a closed container at room temperature away from heat, moisture and direct light. avoid freezing.

Keep away from children.

Do not keep medicines that have expired or are no longer needed.

Ask your doctor how to throw away any unused medicine.


Dispose of used syringes or auto-injectors in a rigid, closed container that needles cannot penetrate. Keep this container away from children and pets.


It is very important that your doctor checks your progress at regular visits. This way your doctor can check that the medicine is working properly and decide whether you should continue to use it and check for any unwanted effects.

Contact your doctor if you have used this medication and have not had good relief. Also, check with your doctor to determine if your migraines or cluster headaches are worse or more frequent than they were before you started taking this medication.

You should not receive this medication if you are using or have used an MAO inhibitor (MAOI) such as phenelzine (Nardil®) or tranylcypromine (Parnate®) within the past 2 weeks. Do not use this medication if you have previously used other triptan medications for migraines. Some examples of triptan medications are almotriptan (Axert®), eletriptan (Relpax®), naratriptan (Amerge®), or zolmitriptan (Zomig®). Some examples of ergot-type drugs are dihydroergotamine (D.H.E. 45®, Migranal®), ergotamine (Bellergal®, Cafergot®, Ergomar®, Wigraine®), or methysergide (Sansert®).

Contact your doctor if you have been using sumatriptan and your migraines got worse or came more often.

The needle cap of the Imitrex® pre-filled syringe contains dried natural rubber (a derivative of latex) which may cause allergic reactions in people sensitive to latex. Tell your doctor if you have a latex allergy before receiving this medication.

This drug may increase your risk of abnormal heart rhythms, heart attack, angina, or stroke. This is more likely if you or a family member already have heart disease, if you have diabetes or high blood pressure, or if you smoke. Call your doctor right away if you have symptoms of a heart problem, such as B. chest pain or discomfort, irregular heartbeat, nausea or vomiting, pain or discomfort in the shoulders, arms, jaw, back or neck, or sweating. Call your doctor at once if you experience stroke symptoms such as confusion, difficulty speaking, double vision, headache, inability to move your arms, legs, or facial muscles, inability to speak, or slow speech.

Talk to your doctor right away if you experience chest discomfort, jaw tightness, or neck tightness after using this medication. Also, tell your doctor if you have sudden or severe abdominal or stomach pain, or bloody diarrhea after using this medication.

Contact your doctor immediately if you experience blurred vision, difficulty reading, or other vision problems during or after treatment. Your doctor may ask you to have an eye exam (ophthalmologist).

Using sumatriptan alone or in combination with other migraine medications for 10 or more days per month can cause the headache to worsen. You can keep a headache diary to record headache frequency and medication use.

Make sure your doctor knows about all other medications you are taking. Sumatriptan can cause a serious condition called serotonin syndrome when used with some medications. These include, in particular, drugs used to treat depression such as citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, olanzapine, paroxetine, sertraline, venlafaxine, Celexa®, Cymbalta®, Effexor®, Lexapro®, Luvox®, Paxil®, Prozac®, Sarafem® , Symbyax® or Zoloft®. See your doctor right away if you experience agitation, confusion, diarrhea, agitation when speaking that is not normal, fever, overactive reflexes, poor coordination, restlessness, tremors, sweating, uncontrollable shaking or shaking, or convulsions. These could be symptoms of serotonin syndrome.

(Video) 💊 What is SUMATRIPTAN?. Side effects, warnings, doses, moa and uses of SUMATRIPTAN (IMITREX).

This drug can cause serious allergic reactions, including anaphylaxis and angioedema. These can be fatal and require immediate medical attention. The most serious signs of this reaction are very rapid or irregular breathing, shortness of breath, or fainting. Other signs may include changes in the color of the skin on the face, a very fast but irregular heartbeat or pulse, lumps on the skin and puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help immediately.

Alcohol consumption can make headaches worse or cause new headaches. People suffering from severe headaches should avoid alcoholic beverages, especially during the headache.

This medicine may make some people feel dizzy, sleepy, or less alert than they normally are. Do not drive or do anything else that might be dangerous until you know how this medicine affects you.

side effects

In addition to the necessary effects, a drug can have some undesirable effects. Although not all of these side effects may occur, they may require medical attention if they do occur.

Contact your doctor immediately if any of the following side effects occur:

less common

  1. blurred vision
  2. pain or discomfort in your chest
  3. chills
  4. confusion
  5. labored or strained breathing
  6. dizziness
  7. Dizziness, fainting, or lightheaded when you get up suddenly from a lying or sitting position
  8. fainting
  9. fast, racing, or irregular heartbeat or pulse
  10. Headache
  11. nervousness
  12. bang in the ears
  13. Trembling in the legs, arms, hands, or feet
  14. slow heartbeat
  15. Sweat
  16. feeling of tension in the head
  17. tightness or pressure in the chest
  18. shaking or trembling of hands or feet
  19. unusual tiredness or weakness


  1. Black stool and tar
  2. blood in the urine
  3. blood in the vomit
  4. Burning when urinating
  5. Cough
  6. decreased urination
  7. Skin depression
  8. Diarrhea
  9. dry mouth
  10. feeling hot or hot
  11. Fever
  12. Reddening or flushing of the skin, especially on the face and neck
  13. feeling generally unwell or sick
  14. inability to move the eyes
  15. Inability to move legs or arms
  16. increase heart rate
  17. increased blinking or twitching of the eyelid
  18. increased sensitivity to pain
  19. increased touch sensitivity
  20. skin indentation
  21. joint pain
  22. Appetitverlust
  23. muscle aches and pains
  24. nausea
  25. Pain in the groin or genitals
  26. pallor of the skin
  27. Pallor or coldness in the tips of the fingers and toes
  28. paralysis on one side of the body
  29. rapid breathing
  30. runny nose
  31. severe or persistent abdominal pain
  32. sharp back pain just below the ribs
  33. Tremble
  34. sore throat
  35. come from the tongue
  36. deep eyes
  37. Property
  38. Tingling in hands and feet
  39. Tingling or pain in your fingers or toes when exposed to cold
  40. sleep disorders
  41. Difficulty speaking or swallowing
  42. uncontrolled twisting movements of the neck, trunk, arms or legs
  43. unusual facial expressions
  44. to throw up
  45. wrinkled skin

unknown incidence

  1. Agitation
  2. Back, leg or stomach pain
  3. bleeding gums
  4. blood in the stool
  5. bluish color of nails, lips, skin, palms, or nail beds
  6. skin color changes
  7. vision changes
  8. decreased awareness or responsiveness
  9. Depression
  10. double vision
  11. general swelling of the body
  12. Headache, sudden, severe and persistent
  13. high fever
  14. hives or itching
  15. hostility
  16. inability to speak
  17. irritability
  18. large, hive-like swelling of the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  19. Loss of the ability to use or understand speech or language
  20. Appetitverlust
  21. loss of consciousness
  22. vision loss
  23. migraine
  24. muscle cramps
  25. noisy breathing
  26. nosebleeds
  27. hyperaktive Reflexe
  28. Pain, tenderness, or swelling of the foot or leg
  29. detect red spots on the skin
  30. bad coordination
  31. Swelling or swelling of the eyelids or around the eyes, face, lips, or tongue
  32. rapid weight gain
  33. rectal bleeding
  34. Redness, pain or itching of the skin
  35. restlessness
  36. seizures
  37. severe or sudden headache
  38. severe drowsiness
  39. slurred speech
  40. Sores, ulcers, or white patches on the lips or inside the mouth
  41. sores, welts, or blisters
  42. abdominal pain and tenderness
  43. swelling of the face, ankles, hands, feet or legs
  44. swollen glands
  45. Speaking or acting with excitement that you cannot control
  46. temporary blindness
  47. shake or shake
  48. conclusion of contract
  49. unexplained bleeding or bruising
  50. unusual bleeding or bruising
  51. unusual sleepiness, dullness, or sluggishness
  52. exceptionally hot skin
  53. Weakness in the arm or leg on one side of the body, sudden and severe
  54. weight loss
  55. yellowing of the eyes or skin

There may be some side effects that do not usually require medical attention. These side effects may go away during treatment as your body gets used to the medicine. Also, your doctor can tell you about ways to prevent or reduce some of these side effects. Contact your doctor if any of the following side effects persist or bother you, or if you have any questions about them:

more often

  1. Bleeding, blistering, burning, cold, skin discolouration, pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, pain, stinging, swelling, tenderness, tingling, ulceration or heat at the injection site
  2. burning or tingling
  3. sleepiness
  4. Feeling of constant movement of self or environment
  5. hot feeling
  6. Redness of the face, neck, arms and occasionally the upper chest
  7. feel relaxed and calm
  8. turning sensation
  9. sleepiness

less common

  1. Angst
  2. bad, unusual, or unpleasant taste (after)
  3. Burning, tingling, itching, numbness, tingling, tingling, or prickling sensation
  4. change in color vision
  5. change in taste
  6. see bad at night
  7. movement difficulties
  8. Discomfort in the jaw, nasal cavity or throat
  9. false or unusual well-being
  10. feel weird
  11. Asia
  12. increased sensitivity of the eyes to sunlight
  13. Joint pain, stiffness or swelling
  14. mental confusion
  15. muscle pain or cramps
  16. neck pain or stiffness
  17. red and sore eyes
  18. upset stomach
  19. swollen joints
  20. teary eyes
  21. Property
  22. weakness


  1. back pain
  2. burping
  3. Bloating or bloating
  4. Changes in speech patterns and rhythms
  5. cramps
  6. dry vomit
  7. excess air or gas in the stomach or intestines
  8. extreme headquarters
  9. profuse bleeding
  10. hiccup
  11. fome
  12. elevation from the seat
  13. Muscle cramp
  14. muscle spasms or convulsions
  15. dor
  16. pass gas
  17. decreased appetite
  18. rhythmic movement of muscles
  19. severe abdominal pain with nausea and vomiting
  20. skin sensitivity

unknown incidence

  1. deafness
  2. Panic
  3. severe sunburn

Some patients may also experience other side effects not listed. If you notice other effects, contact your doctor.

Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Portions of this document were last updated: February 1, 2023

Original article:ânea-route/side-effects/drg-20074378

Copyright © 2023 IBM Watson Health. All rights reserved. The information is for end user use only and may not be sold, redistributed or used for any commercial purpose.

(Video) How to use a sumatriptan autoinjector



Can sumatriptan be given subcutaneously? ›

Sumatriptan has demonstrated efficacy when administered by the subcutaneous, oral, intranasal, or rectal route. Although sumatriptan is primarily used and studied in the setting of migraine headache, it is also an effective agent for cluster headaches.

What are the side effects of sumatriptan injections? ›

Sumatriptan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • pain or redness at the site of injection.
  • flushing.
  • tingling feeling.
  • feeling of warmth.
  • drowsiness.
  • upset stomach.
  • vomiting.
  • muscle cramps.
Dec 15, 2017

How long does it take for sumatriptan side effects to wear off? ›

All forms of sumatriptan are effective and well-tolerated by most patients. The side effects usually resolve within 30 minutes from the time the medication is taken, and only a small number of patients experience serious side effects (Tfelt-Hansen, 1998; Perry, 1998).

How can I reduce the side effects of sumatriptan? ›

How to avoid sumatriptan side effects
  1. Tell the doctor about all medical conditions and medications. ...
  2. Take sumatriptan as directed. ...
  3. Understand the dosing instructions. ...
  4. Do not take sumatriptan or other migraine medications more than 10 times a month. ...
  5. Avoid risky or complex activities. ...
  6. Avoid overtaking stimulants.
Apr 26, 2021

Where do you inject subcutaneous sumatriptan? ›

This medicine is given as a shot under your skin (usually on the stomach, thighs, or upper arms). Sumatriptan injection may sometimes be given at home to patients who do not need to be in a hospital or clinic.

Where do you give Imitrex subcutaneous injection? ›

Sumatriptan Injection is usually injected into the thigh. Carefully read the 'How to use the pre-filled pen' section as provided at the end of this leaflet. The pre-filled pen will inject a dose of Sumatriptan Injection just below the skin quickly and without pain.

Why do I feel weird after taking sumatriptan? ›

You're at higher risk of developing a serious condition called serotonin syndrome if you take these drugs. Symptoms can include agitation, sweating, fast heartbeat, or hallucinations (seeing or hearing things that aren't real). They can also include nausea, vomiting, diarrhea, or loss of balance.

Why does sumatriptan make my body hurt? ›

These results suggest that mild vasoconstriction in peripheral skeletal muscle is associated with the action of sumatriptan and is likely to be the source of the side-effects experienced by some users. Migraine with aura patients were more susceptible to this effect than migraine without aura patients.

How does sumatriptan make you feel? ›

Drowsiness or dizziness, fatigue, tingling or numbness in the fingers or toes, or a feeling of weakness. A sensation of tightness, pain, pressure, or heaviness in the throat, neck, jaw, or over the heart has been reported by some people after taking sumatriptan.

How do I stop sumatriptan rebound headaches? ›

How can I prevent rebound headaches?
  1. Limit the use of any headache medications taken as needed to relieve headache pain to no more than two to three days per a week (or less than 10 days per month).
  2. Contact your doctor if you need to take headache medications more than two days per week.
Nov 7, 2019

Can you sleep after taking sumatriptan? ›

It can make you feel tired or sleepy. If this happens, do not drive and do not use tools or machines. Your chest may feel tight or 'heavy' after taking sumatriptan.

How long does Imitrex make you feel weird? ›

How long side effects from Imitrex last can vary. Some may be temporary, lasting from a few days to a few weeks. For example, injection-site reactions typically are gone within a day or two. But more serious side effects, such as heart problems and stroke, may cause long-term complications.

Who should avoid sumatriptan? ›

Use of sumatriptan is not recommended in elderly patients with kidney problems, heart or blood vessel disease, or high blood pressure, and should not be used by elderly patients with liver problems.

Is sumatriptan hard on the heart? ›

This medicine may increase your risk of having abnormal heart rhythm, heart attack, angina, or stroke. This is more likely to occur if you or a family member already has heart disease, if you have diabetes, high blood pressure, high cholesterol, or if you smoke.

How does sumatriptan affect the brain? ›

Sumatriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the head, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine.

What is the strongest migraine medicine injection? ›

1. Sumatriptan. Prescription triptan drugs can get rid of your acute migraines and cluster headaches in minutes. Sumatriptan, the fastest-working drug on this list, works fastest in injectable form.

How long does it take for sumatriptan injection to work? ›

Timing: It is best to use sumatriptan injection as soon as you notice headache symptoms, but you can also use it after a migraine has already begun. Sumatriptan injection usually starts to work within 10–15 minutes after the injection is given.

How many sumatriptan injections can you take in a month? ›

The maximum recommended dose that may be given in 24 hours is two 20 mg doses. (The 5 mg spray unit should be used for 5 and 10 mg dosages only.) The safety of treating an average of more than 4 migraine headaches in a 30-day period with Sumatriptan has not been established.

How often can you use Imitrex injection? ›

How often can you take Imitrex? You can take Imitrex to treat up to four migraine or cluster headaches a month. This could mean taking Imitrex 4 days in a row or spread out throughout the month. It's not known if it's safe to take Imitrex to treat more than four headaches in any 30-day period.

How often can you get an Imitrex injection? ›

Typical dosing for sumatriptan (Imitrex) injection

Cluster headache: The typical dose is 6 mg injected under the skin once for the treatment of a cluster headache. A second dose may be used at least 1 hour after the first dose if the migraine comes back or doesn't completely go away. The maximum dose is 12 mg per day.

What happens if you take sumatriptan and it's not a migraine? ›

It will not relieve pain other than from migraine headaches. This medicine is usually used for people whose headaches are not relieved by acetaminophen, aspirin, or other pain relievers. Sumatriptan has caused serious side effects in some people, especially people who have heart or blood vessel disease.

Can sumatriptan make you feel worse? ›

Some patients report worsening of the headache or an unpleasant change in its character. This usually lasts for 10 to 30 minutes, but may continue for several hours. Others said the headache recurs within a few hours of initial relief and a second dose is needed after which the migraine usually subsides.

Can sumatriptan cause blood clots? ›

This medicine may cause problems if you have heart disease. If your doctor thinks you might have a problem with this medicine, he or she may want you to take your first dose in the doctor's office or clinic. This medicine may increase your risk of having a blood clot, heart attack, or stroke.

Does sumatriptan raise blood pressure? ›

Conclusion: These findings show that therapeutic doses of sumatriptan acutely increase aortic blood pressure, stiffness, and augmentation index. Noninvasive systolic pulse contour analysis and arterial ultrasound may facilitate detection of drug-induced vascular effects in early clinical trials.

What does rebound headache feel like? ›

Rebound headaches can cause a dull, persistent, tension-type headache that happens either daily or nearly every day. The pain is usually worse in the morning.

How do you break a migraine cycle naturally? ›

Find a calm environment
  1. Turn off the lights. Light and sound can make migraine pain worse. Relax in a dark, quiet room. ...
  2. Try temperature therapy. Apply hot or cold compresses to your head or neck. ...
  3. Sip a caffeinated drink. In small amounts, caffeine alone can relieve migraine pain in the early stages.

Why can you only get 9 sumatriptan a month? ›

There is a reason behind the limit on pills. Headache doctors know that taking triptans more than 10 times a month can actually make migraines more frequent or more severe in some people. Rebound headache, or medication overuse headache, is a pretty common migraine trigger.

Can you drink caffeine with sumatriptan? ›

Dietary caffeine might decrease the effects of levetiracetam and sumatriptan; this needs to be considered in clinical settings. The effectiveness and adverse effects of a levetiracetam–sumatriptan combination should be examined in patients with trigeminal pain.

Why do I feel worse after taking Imitrex? ›

Using Imitrex too often may cause a medication overuse headache (rebound headache). With this side effect, migraine may occur more often, you may develop more cluster headaches, or you may feel migraine-like pain every day.

How common are Imitrex side effects? ›

Migraine Headache
Adverse ReactionIMITREX Injection 6 mg Subcutaneous (n = 547) %Placebo (n = 370) %
28 more rows

How many hours does Imitrex last? ›

Imitrex's half-life is about 2 hours. A half-life is how long it takes for your body to get rid of half of a dose of the drug. In most cases, a drug stays in your system for 4 to 5 half-lives . So Imitrex stays in your system for about 8 to 10 hours.

What works better than sumatriptan? ›

For oral formulations, the time to maximum plasma concentration is reached earlier with rizatriptan than with sumatriptan (1 h versus 2-2.5 h) and rizatriptan has greater bioavailability than sumatriptan (45% versus 15%).

Why is sumatriptan not recommended for over 65? ›

Certain HA drugs, such as the triptans, cannot be used in the older patients with established cardiovascular disease, since the risk of vasospasm is too high [22].

What disease Cannot be used for sumatriptan migraine headaches? ›

Sumatriptan works in part by constricting blood vessels, so it may not be suitable for patients with the following conditions: CAD (coronary artery disease), TIA (transient ischemic attacks), hypertension, vasospasms, Prinzmetal angina, or history of heart attack or uncontrolled high blood pressure.

How much sumatriptan is safe? ›

Adults—25, 50, or 100 milligrams (mg) as a single dose. If you get some relief, or if the migraine comes back after being relieved, another dose may be taken 2 hours after the last dose. Do not take more than 200 mg in any 24-hour period.

What is the danger of triptans? ›

Because triptans antagonize 5-hydroxytriptamine receptors expressed in the cerebrovascular and coronary vessels, triptans as a class are associated with cardiovascular and cerebrovascular risks related to vessel vasoconstriction.

Can sumatriptan cause memory loss? ›

Sumatriptan is a 5-HT1B/1D receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect.

What ways can sumatriptan be administered? ›

Sumatriptan is an abortive medication for migraine attacks, belonging to the triptan family. It is available for administration by four different routes: oral, subcutaneous, intranasal, and rectal.

What angle do you inject sumatriptan? ›

Sumatriptan SUN should be injected subcutaneously using a pre-filled pen. After removal of the needle shield, the open end of the pre-filled pen is to be placed on the injection site, straight up at a right angle (90°).

Does sumatriptan injection burn? ›

The more commonly observed adverse reactions have included those of pressure sensation, flushing, tingling, dizziness/vertigo, warm/hot sensation, burning sensation, flushing, and numbness; formulation specific events including injection site reactions, application site pain, and nasal discomfort have been reported.

How is sumatriptan taken? ›

Sumatriptan comes as a tablet to take by mouth. It is usually taken at the first sign of a migraine headache.If your symptoms improve after you take sumatriptan but return after 2 hours or longer, you may take a second tablet.


1. What i use to help relieve side effects of triptans. Sumatriptan Imitrex
2. Humphrey, Pat 04 Sumatriptan – safety issues
(hist modbiomed)
3. Sumatriptan Oral Tablet Patient Counseling
(Drug Information Specialist)
4. Sumatriptan serotonin agonist | MOA |Sulfhaemoglobinemia | adverse effects
(Pill Reaction)
5. How is Sumatriptan (Imitrex) Taken?
(Drug Talk)
6. Sumatriptan Pharmacology, MOA, Uses, Indications, Contraindications and Side effects
(Oce Medico)
Top Articles
Latest Posts
Article information

Author: Kelle Weber

Last Updated: 03/01/2023

Views: 5390

Rating: 4.2 / 5 (73 voted)

Reviews: 88% of readers found this page helpful

Author information

Name: Kelle Weber

Birthday: 2000-08-05

Address: 6796 Juan Square, Markfort, MN 58988

Phone: +8215934114615

Job: Hospitality Director

Hobby: tabletop games, Foreign language learning, Leather crafting, Horseback riding, Swimming, Knapping, Handball

Introduction: My name is Kelle Weber, I am a magnificent, enchanting, fair, joyous, light, determined, joyous person who loves writing and wants to share my knowledge and understanding with you.